Nonsteroidal Antiinflammatory Drugs

Oct 5, 06:11 am

The very name of this group of drugs said to be appointed. A 'non-steroid' they said, because most anti-inflammatory effect of glucocorticosteroids have it (see steroids), and in this case we are talking about a completely different group with a fundamentally different mechanism of action. NSAIDs include most, perhaps, a certain drug in the world - Aspirin. Everyone knows why you need it. He takes off pain, 'knocks' temperature reduces manifestations of the inflammatory process. Actually, this has three main effects of NSAIDs. The mechanism of action of these drugs is reduced to the fact that they block the synthesis of certain compounds in the body (called prostaglandins) that lead to sensations of pain, fever, increased blood flow in the inflamed tissue, as well as enhance aggregation of blood (see antiplatelet agents). However, not all preparations of NSAIDs are equally blocked all of these reactions.

Scope of NSAIDs is very wide: they are used in acute illness accompanied by high temperature, anti- action is necessary in the treatment of rheumatic diseases, including those involving articular pains, they are used in cardiology for the prevention of thrombosis. However, they all (except the newest drugs This group, which is not enough available) have a significant side effect - they stimulate the appearance of the mucous membrane of the gastrointestinal tract erosions and ulcers. The mechanism of this action is based on the fact that blocking production of prostaglandins, they deprive the mucosa of the natural factor of protection against the aggressive effects of gastric juice, which can lead to the formation of stomach ulcers. This effect, called 'ulcerogenic' manifested in nsaid for the duration of their admission (ordinary course of several days does not usually lead to serious violations of the integrity of the mucous membrane). Therefore, in the case of treatment, such as arthritis is necessary to monitor the state of digestive system. Need to know that among the anesthetic drugs have many, which include the analgin (metamizol). In most countries their production of either expire or their application is extremely limited. This is due to the high toxicity of metamizol, until death. It is better not to use these drugs at all. Second, you need to know about these medications: Aspirin should not be given to children under 7 years (especially at the slightest suspicion of a viral infection - acute respiratory infections, chickenpox, flu) because in these cases may develop a dangerous complication - Reye syndrome, which affects the liver and brain.
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